Active Ingredient: Norfloxacin
For these reasons, before you start taking norfloxacin it is important that your doctor knows: If you are pregnant, trying for a baby, or breast-feeding.
If you are under 18 years of age.
Desensitization is a useful procedure in immediate and some delayed reactions, if a suitable alternative antibiotic is not available.
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At the respective doses, mean peak serum and plasma concentrations of 0.
The effective half-life of norfloxacin in serum and plasma is 3—4 hours. Steady-state concentrations of norfloxacin will be attained within two days of dosing. Norfloxacin is least soluble at urinary pH of 7. Other companies initiated fluoroquinolone discovery programs in the aftermath of the publication of the norfloxacin patent.
Bayer Pharmaceuticals discovered that the addition of a single carbon atom to the norfloxacin structure provided another 4 to 10-fold improvement in activity.
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Patients taking any of these drugs concomitantly with norfloxacin should be substantially monitored.
In particular, he represented more toxic, such as ibuprofen, concomitant administration of nonsteroidal completion-inflammatory drugs such as phenylbutazone and indomethacin with quinolones has been observed to enhance the CNS stimulatory effect of quinolones.