Active Ingredient: Ivermectin
The PBAC noted that ivermectin is not ovicidal, and considered that this underlined the importance of using both doses of ivermectin to ensure complete eradication.
The PBAC considered such practice could increase the efficacy of the treatment and mitigate against the development of mite-resistance to ivermectin.
Clinical Place for the Proposed Therapy Scabies is a parasitic infestation of the skin caused by the mite Sarcoptes scabiei, var hominis, a human pathogen, which is spread by close physical contact between infected persons.
Whilst the majority of patients suffer from typical scabies, some patients develop crusted scabies, a severe form of scabies characterised by crusted lesions affecting the palms and soles, and thickened and dystrophic nails.
Scabies infestation can lead to pyoderma, skin sores infested with bacteria, especially group A streptococcus or Staphylococcus aureus.
For crusted scabies, ivermectin plus topical treatment including PBS listed permethrin is proposed as first line treatment of crusted scabies.
Ivermectin is proposed for the treatment of patients who have failed topical therapy.
The PBAC considered that ivermectin in conjunction with topical treatment is currently the only effective treatment for crusted scabies, while the appropriate clinical place of ivermectin for the treatment of typical scabies in practice was after the failure of permethrin and benzyl benzoate.
Comparator The submission proposed placebo as the main comparator. The PBAC considered this the appropriate comparator for the treatment of crusted scabies.
We believe that this additional service is useful to you because it allows you to carry on with a reservation without having to search for the service items again or fill in all the reservation details from scratch.
Market research: We sometimes ask our customers to take part in market research. Any additional personal details that you give us as part of the market research will only be used with your consent. Improving our services: Finally, we use personal information for analytical purposes, to improve our services, enhance the user experience, and improve the functionality and quality of our online travel services.
How does Traveler use social media? For example, we integrated social media plugins into the Traveler website. So when you click on one of the buttons and register with your social media account, information is shared with your social media provider, and possibly presented on your social media profile to be shared with others in your network.
In addition to implementing these buttons, Traveler uses social media by maintaining accounts on several social media sites and by offering social apps. This information is necessary to create a unique user experience either in the app itself or on our website.
It facilitates things like personalizing our website to suit your needs, connecting you with your friends on travel destinations and analyzing and enhancing our travel-related services. Your social media provider will be able to tell you more about how they use and process your data in such cases.
How does Traveler share your data with third parties? To find out more about the Traveler corporate family, visit About Traveler.
Your information might also be shared with other members of the Traveler group for example: Agoda.
We also work with third-party advertisement networks to market our accommodation and services on other platforms, or involve third-party providers for analytical purposes.
These third parties involved in any of these services will be bound by confidentiality agreements and will not be allowed to use your personal information for any purposes other than those specified above.
In this context, your information is governed by the privacy policies of these business partners. Business partners: We work with business partners around the world to distribute or advertise services and to help our business partners distribute and advertise their travel-related services.
How does Traveler use mobile devices? We have free apps for a variety of mobile devices and use versions of our regular website that have been optimized for mobile.