Active Ingredient: Orlistat
The following information was supplied regarding data availability: The raw data are available in the Supplemental Files.
Abstract Background Overweight and abdominal obesity, in addition to medical conditions such as high blood pressure, high blood sugar and triglyceride levels, are typical risk factors associated with metabolic syndrome.
For this purpose, the further development of both in vitro and in vivo models appears to be strongly justified. Various modes of probiotic action were elucidated by using in vitro studies including development of dedicated in vitro models while efficacy was investigated by both in vivo preclinical studies Park et al.
These therapeutic benefits were all related to anti-obesity effects of probiotics Kadooka et al.
The concept of a minimal effective dose is complicated due to the large and diverse number of microbial and host-related factors Salminen et al.
Yet, substantial evidence supports the principle of dose-dependency of probiotics to modulate systemic and mucosal immune function, improve intestinal barrier function, alter gut microbiota, and exert metabolic effects on the host, also in a strain-dependent manner Alemka et al.
Inclusion criteria for studies were: 1 randomized trial, 2 obesity intervention in US adults, and 3 conducted in primary care or explicitly intended to model a primary care setting. But an OTC version of the drug would need to rely on its packaging, not a doctor's advice, to communicate all this information.
There's also a Web site with exercise tips, more menu plans, a message board, and a way to create an individualized food schedule. The orlistat educational effort wins praise from Morgan Downey, executive director of the Obesity Society, an advocacy group for physicians.
Other observers are more skeptical. With label changes, the agency approved the OTC application 10 months later.
One of the company's most dramatic marketing decisions was to pick a new name. As Burton tells the story, one person picked up the theme, saying, "We're the honest ally in weight loss.
Xenical became alli, pronounced like the noun "ally, and a marketing campaign began.
That's alli with a lower-case 'a. But, why not keep the original Xenical name? Plenty of drugs that go over-the-counter don't switch names, such as Claritin, the allergy medication.